Product details
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METTL11A rabbit pAb
Ucallm_WP8570-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | NTMT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 25kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human METTL11A |
| Specificity | This antibody detects endogenous levels of METTL11A at Human, Mouse,Rat |
| Gene Name | NTMT1 C9orf32 METTL11A NRMT AD-003 |
| Protein Name | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) |
| Other Name | |
| Species | Human |
| Gene ID | 28989 |
| Uniprot | Q9BV86, |
| Species.1 | Mouse |
| Gene ID.1 | 66617 |
| Uniprot.1 | Q8R2U4, |
| Species.2 | Rat |
| Gene ID.2 | 362103 |
| Uniprot.2 | Q5BJX0 |
| Cellular Localization | Nucleus . Predominantly nuclear (PubMed:24090352). |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation . Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. |
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