MFGM Polyclonal Antibody
Ucallm_WP2465-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Specifications
| Size | 50μL/100μL |
| Target | MFGM |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MFGM Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MFGE8 |
| Protein Name | Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] |
| Other Name | |
| Species | Human |
| Gene ID | 4240 |
| Uniprot | Q08431, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P21956, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P70490 |
| Cellular Localization | Membrane; Peripheral membrane protein . Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein . Located in the acrosomal region of zona-pellucida bound sperm. . |
| Tissue Expression | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Medin is the main constituent of aortic medial amyloid.,Function:Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.,PTM:Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 2 F5/8 type C domains.,similarity:Contains 3 F5/8 type C domains.,tissue specificity:Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas., |
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