Product details
Background:
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004],
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MGRN1 Polyclonal Antibody
Ucallm_WP3277-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MGRN1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MGRN1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MGRN1 KIAA0544 RNF156 |
| Protein Name | E3 ubiquitin-protein ligase MGRN1 (Mahogunin RING finger protein 1) (RING finger protein 156) |
| Other Name | |
| Species | Human |
| Gene ID | 23295 |
| Uniprot | O60291, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D074, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5XIQ4 |
| Cellular Localization | Early endosome . The endosomal localization is dependent on the interaction with TSG101.; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; [Isoform 4]: Cytoplasm, cytosol. Cell membrane. |
| Tissue Expression | Brain,Leukocyte, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway;Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis |
| Research Areas | >>Ubiquitin mediated proteolysis; / >>Hedgehog signaling pathway |
| Function | Domain:The RING finger is required for ubiquitin ligase activity.,Function:Probable E3 ubiquitin-protein ligase.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated in vitro.,similarity:Contains 1 RING-type zinc finger., |
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