Price range: $268.00 through $328.00
Background:
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
| Size | 50μL/100μL |
| Target | MICA1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| MW(Calculated) | 117kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MICA1 AA range: 155-205 |
| Specificity | This antibody detects endogenous levels of MICA1 at Human/Mouse/Rat |
| Gene Name | MICAL1 MICAL NICAL |
| Protein Name | MICA1 |
| Other Name | |
| Species | Human |
| Gene ID | 64780 |
| Uniprot | Q8TDZ2, |
| Species.1 | Mouse |
| Gene ID.1 | 171580 |
| Uniprot.1 | Q8VDP3, |
| Species.2 | Rat |
| Gene ID.2 | 294520 |
| Uniprot.2 | D3ZBP4 |
| Cellular Localization | Cytoplasm. Cytoplasm, cytoskeleton. Midbody . Accumulates transiently at the abscission site before abscission occurs. . |
| Tissue Expression | Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:FAD .,Domain:The C-terminal coiled coil part contains the plexin-interacting region.,Function:May be a cytoskeletal regulator that connects NEDD9 to intermediate filaments.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 LIM zinc-binding domain.,subunit:Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.,tissue specificity:Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells., |
