Price range: $268.00 through $328.00
Background:
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008],
| Size | 50μL/100μL |
| Target | MINA |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 51kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MINA Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | MINA MDIG MINA53 NO52 |
| Protein Name | MYC-induced nuclear antigen (Mineral dust-induced gene protein) (Nucleolar protein 52) |
| Other Name | |
| Species | Human |
| Gene ID | 84864 |
| Uniprot | Q8IUF8, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8CD15, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q8CFC1 |
| Cellular Localization | Nucleus . Nucleus, nucleolus . |
| Tissue Expression | Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.,induction:Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.,sequence Caution:Translated as Trp.,similarity:Belongs to the MINA53/NO66 family.,similarity:Contains 1 JmjC domain.,tissue specificity:Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines., |
