Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | MIP-1β |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 16kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CCL4. AA range:41-90 |
| Specificity | MIP-1β Polyclonal Antibody detects endogenous levels of MIP-1β protein. |
| Gene Name | CCL4 |
| Protein Name | C-C motif chemokine 4 |
| Other Name | CCL4; / LAG1; / MIP1B; / SCYA4; / C-C motif chemokine 4; / G-26 T-lymphocyte-secreted protein; / HC21; / Lymphocyte activation gene 1 protein; / LAG-1; / MIP-1-beta; / 1-69; / Macrophage inflammatory protein 1-beta; / MIP-1-beta; / PAT 744; / Protein H400; / SIS-gamma; / Small-inducible cytokine A4; / T-cell activation protein 2; / ACT-2 |
| Species | Human |
| Gene ID | 388372 |
| Uniprot | P13236, |
| Species.1 | Mouse |
| Gene ID.1 | 20303 |
| Uniprot.1 | P14097 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Blood,Brain,Lung,Natural killer cell,T-cell, |
| Signaling_pathway | Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>NF-kappa B signaling pathway; / >>Toll-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway; / >>Human cytomegalovirus infection |
| Function | Alternative products:CCL4L1 and CCL4L2 genes differ in their non-coding regions. Thus, alternative splicing events differ between the two genes,Caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,Function:Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.,Function:Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.,induction:By mitogens.,online information:Macrophage inflammatory protein entry,polymorphism:The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.,PTM:N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).,subunit:Interacts with CCR5.,tissue specificity:Detected in B-cells., |
