Price range: $268.00 through $328.00
Background:
function:Play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules., similarity:Belongs to the TRAF3IP1 family., subcellular location:Microtubules., subunit:Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1., tissue specificity:Ubiquitous.,
| Size | 50μL/100μL |
| Target | MIP-T3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 78kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MIPT3. AA range:221-270 |
| Specificity | MIP-T3 Polyclonal Antibody detects endogenous levels of MIP-T3 protein. |
| Gene Name | TRAF3IP1 |
| Protein Name | TRAF3-interacting protein 1 |
| Other Name | TRAF3IP1; / MIPT3; / TRAF3-interacting protein 1; / Interleukin-13 receptor alpha 1-binding protein 1; / Microtubule-interacting protein associated with TRAF3; / MIP-T3 |
| Species | Human |
| Gene ID | 26146 |
| Uniprot | Q8TDR0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q149C2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body . Microtubules (PubMed:12935900). In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip (PubMed:26487268). . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.,similarity:Belongs to the TRAF3IP1 family.,subcellular location:Microtubules.,subunit:Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1.,tissue specificity:Ubiquitous., |
