Product details
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MKRN2 rabbit pAb
Ucallm_WP6963-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MKRN2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 46kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MKRN2 |
| Specificity | This antibody detects endogenous levels of MKRN2 at Human, Mouse |
| Gene Name | MKRN2 RNF62 HSPC070 |
| Protein Name | Probable E3 ubiquitin-protein ligase makorin-2 (RING finger protein 62) |
| Other Name | |
| Species | Human |
| Gene ID | 23609 |
| Uniprot | Q9H000, |
| Species.1 | Mouse |
| Gene ID.1 | 67027 |
| Uniprot.1 | Q9ERV1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . |
| Tissue Expression | Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940). Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136). |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). |
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