Product details
Background:
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008],
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MN1 Polyclonal Antibody
Ucallm_WP13207-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MN1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 135kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MN1. AA range:821-870 |
| Specificity | MN1 Polyclonal Antibody detects endogenous levels of MN1 protein. |
| Gene Name | MN1 |
| Protein Name | Probable tumor suppressor protein MN1 |
| Other Name | MN1; / Probable tumor suppressor protein MN1 |
| Species | Human |
| Gene ID | 4330 |
| Uniprot | Q10571 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12; 22)(p13; q11) with TEL.,Disease:Defects in MN1 may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.,Function:May play a role in tumor suppression.,tissue specificity:Ubiquitously expressed. Highest levels in skeletal muscle., |
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