Name: Mnk1 Polyclonal Antibody
SKU: WP13209
Price: 268 USD
Availability: InStock

Mnk1 Polyclonal Antibody

Ucallm_WP13209-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP13209-100

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Product details

Background:

MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],

Specifications

Size	50μL/100μL
Target	Mnk1
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	51kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human MKNK1. AA range:111-160
Specificity	Mnk1 Polyclonal Antibody detects endogenous levels of Mnk1 protein.
Gene Name	MKNK1
Protein Name	MAP kinase-interacting serine/threonine-protein kinase 1
Other Name	MKNK1; / MNK1; / MAP kinase-interacting serine/threonine-protein kinase 1; / MAP kinase signal-integrating kinase 1; / MAPK signal-integrating kinase 1; / Mnk1
Species	Human
Gene ID	8569
Uniprot	Q9BUB5,
Species.1	Mouse
Gene ID.1	17346
Uniprot.1	O08605
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	[Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.
Tissue Expression	Ubiquitous.
Signaling_pathway	Organismal Systems >> Endocrine system >> Insulin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas	>>MAPK signaling pathway; / >>HIF-1 signaling pathway; / >>Insulin signaling pathway
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.,Function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.,tissue specificity:Ubiquitous.,

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Mnk1 Polyclonal Antibody

Product details

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Mnk1 Polyclonal Antibody

Product details

Specifications

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