Price range: $288.00 through $368.00
Background:
The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
| Size | 50μL/100μL |
| Target | MOB1A/B Phospho Thr12 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human MOB1 (Thr12) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat MOB1 (phospho-Thr12) |
| Gene Name | |
| Protein Name | MOB1 (Thr12) |
| Other Name | MOB kinase activator 1A; / Mob1 alpha; / Mob1A; / Mob1 homolog 1B; / Mps one binder kinase activator-like 1B |
| Species | Human |
| Gene ID | 55233 |
| Uniprot | Q9H8S9;Q7L9L4, |
| Species.1 | Mouse |
| Gene ID.1 | 232157 |
| Uniprot.1 | Q921Y0;Q8BPB0, |
| Species.2 | Rat |
| Gene ID.2 | 297387 |
| Uniprot.2 | Q3T1J9 |
| Cellular Localization | cytosol,extracellular exosome, |
| Tissue Expression | Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway - multiple species |
| Research Areas | >>Hippo signaling pathway; / >>Hippo signaling pathway - multiple species |
| Function | Function:Stimulates the kinase activity of STK38 and STK38L.,PTM:Phosphorylated.,similarity:Belongs to the MOB1/phocein family.,subunit:Binds STK38 and STK38L., |
