Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
| Size | 50μL/100μL |
| Target | MOB1A/B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 24kD |
| MW(Observed) | 24kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0421R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | HSPB1 |
| Protein Name | MOB1 |
| Other Name | MOB kinase activator 1A; / Mob1 alpha; / Mob1A; / Mob1 homolog 1B; / Mps one binder kinase activator-like 1B |
| Species | Human |
| Gene ID | 3315 |
| Uniprot | Q9H8S9;Q7L9L4, |
| Species.1 | Mouse |
| Gene ID.1 | 232157 |
| Uniprot.1 | Q921Y0;Q8BPB0, |
| Species.2 | Rat |
| Gene ID.2 | 297387 |
| Uniprot.2 | Q3T1J9 |
| Cellular Localization | Cytoplasm, Nucleus |
| Tissue Expression | Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> VEGF signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>VEGF signaling pathway; / >>Amoebiasis |
| Function | Function:Stimulates the kinase activity of STK38 and STK38L.,PTM:Phosphorylated.,similarity:Belongs to the MOB1/phocein family.,subunit:Binds STK38 and STK38L., |
