Mox1 Polyclonal Antibody
Ucallm_WP13221-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012],
Specifications
| Size | 50μL/100μL |
| Target | Mox1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NOX1. AA range:436-485 |
| Specificity | Mox1 Polyclonal Antibody detects endogenous levels of Mox1 protein. |
| Gene Name | NOX1 MOX1 NOH1 |
| Protein Name | NADPH oxidase 1 |
| Other Name | NOX1; / MOX1; / NOH1; / NADPH oxidase 1; / NOX-1; / Mitogenic oxidase 1; / MOX-1; / NADH/NADPH mitogenic oxidase subunit P65-MOX; / NOH-1 |
| Species | Human |
| Gene ID | 27035 |
| Uniprot | Q9Y5S8, |
| Species.1 | Mouse |
| Gene ID.1 | 237038 |
| Uniprot.1 | Q8CIZ9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell projection, invadopodium membrane; Multi-pass membrane protein . Cell membrane . |
| Tissue Expression | NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells. |
| Signaling_pathway | Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Osteoclast differentiation; / >>AGE-RAGE signaling pathway in diabetic complications; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis |
| Function | cofactor:FAD .,cofactor:NADP .,enzyme regulation:The oxidase activity is potentiated by NOXA1 and NOXO1.,Function:NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.,tissue specificity:NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells., |
Please login to post questions
Related products
