MPP4 rabbit pAb
Ucallm_WP4230-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | MPP4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 70kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MPP4 AA range: 388-438 |
| Specificity | This antibody detects endogenous levels of MPP4 at Human/Mouse/Rat |
| Gene Name | MPP4 ALS2CR5 DLG6 |
| Protein Name | MPP4 |
| Other Name | |
| Species | Human |
| Gene ID | 58538 |
| Uniprot | Q96JB8, |
| Species.1 | Mouse |
| Gene ID.1 | 227157 |
| Uniprot.1 | Q6P7F1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9QYH1 |
| Cellular Localization | Cytoplasm . Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ). |
| Tissue Expression | Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction |
| Research Areas | >>Tight junction |
| Function | Function:May play a role in retinal photoreceptors development.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 L27 domains.,subcellular location:Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).,subunit:Interacts with MPDZ. May interact with GRIA2 (By similarity). Forms a complex with CRB1 and MPP5.,tissue specificity:Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific., |
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