Name: U-Blot® MX1 Rabbit mAb
SKU: WR4328
Price: 268 USD
Availability: InStock

U-Blot® MX1 Rabbit mAb

A549 cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with primary antibody 1:1000. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4328 A549 cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with primary antibody 1:1000. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4328-50

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Product details

Background:This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Specifications

Size	50μL/100μL
Target	MX1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	76kD
MW(Observed)	76kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0534R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	MX1
Protein Name	Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]
Other Name
Species	Human
Gene ID	4599
Uniprot	P20591,
Species.1	Mouse
Gene ID.1
Uniprot.1	P09922,
Species.2	Rat
Gene ID.2
Uniprot.2	P18588
Cellular Localization	Cytoplasm . Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region . Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). .; [Isoform 2]: Cytoplasm . Nucleus . Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). .
Tissue Expression	Primary B-Cells,Spleen,Uterus,
Signaling_pathway
Research Areas	>>Viral life cycle - HIV-1; / >>Hepatitis C; / >>Measles; / >>Influenza A; / >>Human papillomavirus infection; / >>Coronavirus disease - COVID-19
Function	Function:May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus.,induction:By interferons.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,subunit:Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.,