Name: Myd88 Mouse mAb [2H12]
SKU: WM1108
Price: 268 USD
Availability: InStock

Product details

Background:
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

Specifications

Size	50μL/100μL
Target	Myd88
Reactivity	Human, Mouse, Rat
Applications	IHC
MW(Calculated)
MW(Observed)	33kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	2H12
Immunogen	Synthesized peptide derived from human Myd88
Specificity	This antibody detects endogenous levels of Myd88 at Human, Mouse,Rat
Gene Name	MYD88
Protein Name	Myd88
Other Name	Myeloid differentiation primary response protein MyD88
Species	Human
Gene ID	4615
Uniprot	Q99836,
Species.1	Mouse
Gene ID.1	17874
Uniprot.1	P22366,
Species.2	Rat
Gene ID.2	301059
Uniprot.2	Q6Y1S1
Cellular Localization	Cytoplasm . Nucleus .
Tissue Expression	Ubiquitous.
Signaling_pathway	Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Research Areas	>>MAPK signaling pathway; / >>NF-kappa B signaling pathway; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>Alcoholic liver disease; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Pertussis; / >>Legionellosis; / >>Yersinia infection; / >>Leishmaniasis; / >>Chagas disease; / >>African trypanosomiasis; / >>Malaria; / >>Toxoplasmosis; / >>Tuberculosis; / >>Hepatitis B; / >>Measles; / >>Influenza A; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Coronavirus disease - COVID-19; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Lipid and atherosclerosis
Function	Disease:Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also called recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.,Function:Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation.,similarity:Contains 1 death domain.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1 and IRAK2 via their respective TIR domains. Interacts with IL1RL1.,tissue specificity:Ubiquitous.,