Myeloperoxidase [MPO] [PTR2562] mouse mAb
Ucallm_WM1360-50
Price range: $268.00 through $328.00
Product details
Background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Specifications
| Size | 50μL/100μL |
| Target | Myeloperoxidase |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 84kD |
| MW(Observed) | 70kD |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR2562 |
| Immunogen | Synthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450 |
| Specificity | This antibody detects endogenous levels of MPO protein. |
| Gene Name | MPO |
| Protein Name | Myeloperoxidase |
| Other Name | 84 kDa myeloperoxidase antibody; / 89 kDa myeloperoxidase antibody; / EC1.11.2.2 antibody; / fj80f04 antibody; / MPO antibody; / mpx antibody; / myeloid-specific peroxidase antibody; / Myeloperoxidase antibody; / Myeloperoxidase heavy chain antibody; / Myeloperoxidase light chain antibody; / PERM_HUMAN antibody; / wu:fj80f04 antibody |
| Species | Human |
| Gene ID | 4353 |
| Uniprot | P05164, |
| Species.1 | Mouse |
| Gene ID.1 | 17523 |
| Uniprot.1 | P11247, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | D3ZGE2 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Leukemia,Leukocyte,Liver,Plasma,Saliva |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia |
| Research Areas | >>Drug metabolism - other enzymes; / >>Phagosome; / >>Neutrophil extracellular trap formation; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia |
| Function | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971). |
Please login to post questions
Related products
