Name: Nkx-2.5 Monoclonal Antibody
SKU: WM0343
Price: 268 USD
Availability: InStock

Nkx-2.5 Monoclonal Antibody

Ucallm_WM0343-50

Price range: $268.00 through $328.00

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100μl

50μl

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SKU: WM0343-50

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Product details

Background:
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Specifications

Size	50μL/100μL
Target	Nkx-2.5
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	35kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	6G4
Immunogen	Purified recombinant fragment of human Nkx-2.5 expressed in E. Coli.
Specificity	Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.
Gene Name	NKX2-5
Protein Name	Homeobox protein Nkx-2.5
Other Name	NKX2-5; / CSX; / NKX2.5; / NKX2E; / Homeobox protein Nkx-2.5; / Cardiac-specific homeobox; / Homeobox protein CSX; / Homeobox protein NK-2 homolog E
Species	Human
Gene ID	1482
Uniprot	P52952,
Species.1	Mouse
Gene ID.1
Uniprot.1	P42582
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Expressed only in the heart.
Signaling_pathway
Research Areas
Function	Disease:Defects in NKX2-5 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,Disease:Defects in NKX2-5 are the cause of atrial septal defect with atrioventricular conduction defects (ASD-AVCD) [MIM:108900]. ASD-AVCD is a congenital heart malformation characterized by atrioventricular conduction defects and incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.,Disease:Defects in NKX2-5 are the cause of congenital hypothyroidism non-goitrous type 5 (CHNG5) [MIM:225250]. CHNG5 is a non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG5 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland.,Function:Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4.,online information:Congenital heart disease website,similarity:Belongs to the NK-2 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1.,tissue specificity:Expressed only in the heart.,