Oct-2 [ABT211] mouse mAb
Ucallm_WM1679-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Specifications
| Size | 50μL/100μL |
| Target | Oct-2 |
| Reactivity | Human, Mouse |
| Applications | IHC, ELISA |
| MW(Calculated) | 51kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM211 |
| Immunogen | Synthesized peptide derived from human Oct-2 AA range: 250-350 |
| Specificity | The antibody can specifically recognize human Oct-2 protein. |
| Gene Name | POU2F2 OCT2 OTF2 |
| Protein Name | Oct-2 |
| Other Name | POU domain, class 2, transcription factor 2; / Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; / Octamer-binding protein 2; / Oct-2; / Octamer-binding transcription factor 2; / OTF-2 |
| Species | Human |
| Gene ID | 5452 |
| Uniprot | P09086 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. |
| Signaling_pathway | |
| Research Areas | >>Herpes simplex virus 1 infection; / >>Lipid and atherosclerosis |
| Function | Function:Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR and PGR.,tissue specificity:Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147., |
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