Specifications
| Size | 50μL/100μL |
| Target | NOTCH3 |
| Reactivity | Human, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 244kD |
| MW(Observed) | 90kD(fragment),270kD(full length) |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1351R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | NOTCH3 |
| Protein Name | NOTCH3 (Cleaved-Asp1628) |
| Other Name | Neurogenic locus notch homolog protein 3; / Notch 3; / [Cleaved into: Notch 3 extracellular truncation; / Notch 3 intracellular domain] |
| Species | Human |
| Gene ID | 4854 |
| Uniprot | Q9UM47, |
| Species.1 | Mouse |
| Gene ID.1 | 18131 |
| Uniprot.1 | Q61982, |
| Species.2 | Rat |
| Gene ID.2 | 56761 |
| Uniprot.2 | Q9R172 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. |
| Tissue Expression | Ubiquitously expressed in fetal and adult tissues. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> Notch signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Endocrine resistance; / >>Notch signaling pathway; / >>Apelin signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Thyroid hormone signaling pathway; / >>Human papillomavirus infection; / >>Pathways in cancer; / >>MicroRNAs in cancer; / >>Breast cancer |
| Function |
