P70 S6 Kinase mouse Monoclonal Antibody [1C7]
Ucallm_WM1179-50
Price range: $268.00 through $328.00
Product details
Background:
ribosomal protein S6 kinase B1(RPS6KB1) Homo sapiens This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013],
Specifications
| Size | 50μL/100μL |
| Target | p70 S6 kinase α |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 70,85kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 1C7 |
| Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
| Specificity | P70 S6 Kinase protein detects endogenous levels of RPS6KB1 |
| Gene Name | RPS6KB1 STK14A P70S6K |
| Protein Name | Ribosomal protein S6 kinase beta-1 |
| Other Name | RPS6KB1; / STK14A; / Ribosomal protein S6 kinase beta-1; / S6K-beta-1; / S6K1; / 70 kDa ribosomal protein S6 kinase 1; / P70S6K1; / p70-S6K 1; / Ribosomal protein S6 kinase I; / Serine/threonine-protein kinase 14A; / p70 ribosomal S6 kinase alpha; / p70 S6 kinas |
| Species | Human |
| Gene ID | 6198 |
| Uniprot | P23443, |
| Species.1 | Mouse |
| Gene ID.1 | 72508 |
| Uniprot.1 | Q8BSK8, |
| Species.2 | Rat |
| Gene ID.2 | 83840 |
| Uniprot.2 | P67999 |
| Cellular Localization | Cell junction, synapse, synaptosome . Mitochondrion outer membrane. Mitochondrion. Colocalizes with URI1 at mitochondrion.; [Isoform Alpha I]: Nucleus. Cytoplasm.; [Isoform Alpha II]: Cytoplasm. |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Cancer: specific types >> Colorectal cancer;Human Diseases >> Cancer: specific types >> Pancreatic cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>EGFR tyrosine kinase inhibitor resistance; / >>Endocrine resistance; / >>ErbB signaling pathway; / >>HIF-1 signaling pathway; / >>Autophagy - animal; / >>mTOR signaling pathway; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>TGF-beta signaling pathway; / >>Apelin signaling pathway; / >>Fc gamma R-mediated phagocytosis; / >>Thermogenesis; / >>Insulin signaling pathway; / >>Insulin resistance; / >>Shigellosis; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Human immunodeficiency virus 1 infection; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Colorectal cancer; / >>Pancreatic cancer; / >>Acute myeloid leukemia; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer; / >>Choline metabolism in cancer; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase.,Function:Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1R9A/neurabin-1.,tissue specificity:Widely expressed., |
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