Specifications
| Size | 50μL/100μL |
| Target | Pax 8 |
| Reactivity | Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 48kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 2B11 |
| Immunogen | Synthesized peptide derived from human PAX-8 |
| Specificity | This antibody detects endogenous levels of PAX-8 at Mouse |
| Gene Name | PAX8 |
| Protein Name | PAX-8 |
| Other Name | Paired box protein Pax-8 |
| Species | Human |
| Gene ID | 7849 |
| Uniprot | Q06710, |
| Species.1 | Mouse |
| Gene ID.1 | 18510 |
| Uniprot.1 | Q00288, |
| Species.2 | Rat |
| Gene ID.2 | 81819 |
| Uniprot.2 | P51974 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Expressed in the excretory system, thyroid gland and Wilms tumors. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Thyroid cancer |
| Research Areas | |
| Function | Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,Disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,Function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.,similarity:Contains 1 paired domain.,tissue specificity:Expressed in the excretory system, thyroid gland and Wilms tumors., |
