PAX2 [PTR1301] mouse mAb
Ucallm_WM1342-50
Price range: $268.00 through $328.00
Product details
Background:
paired box 2(PAX2) Homo sapiens PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Specifications
| Size | 50μL/100μL |
| Target | Pax-2 |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMR1301 |
| Immunogen | Synthesized peptide derived from human PAX2. AA range: 150-250 |
| Specificity | This antibody detects endogenous levels of PAX2 protein. |
| Gene Name | PAX2 |
| Protein Name | Paired box protein Pax-2 |
| Other Name | PAX2; / Paired box protein Pax-2 |
| Species | Human |
| Gene ID | 5076 |
| Uniprot | Q02962, |
| Species.1 | Mouse |
| Gene ID.1 | 18504 |
| Uniprot.1 | P32114 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. |
| Signaling_pathway | |
| Research Areas | |
| Function | Transcription factor that may have a role in kidney cell differentiation . Has a critical role in the development of the urogenital tract, the eyes, and the CNS. |
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