Name: PP2A α and β mouse mAb
SKU: WM0598
Price: 268 USD
Availability: InStock

Product details

Background:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010],

Specifications

Size	50μL/100μL
Target	PP2A α and β
Reactivity	Human, Mouse, Rat
Applications	WB, IP
MW(Calculated)
MW(Observed)	36kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	4C9
Immunogen	Purified recombinant human full length PP2A beta protein expressed in E.coli
Specificity	This antibody detects endogenous levels of PP2A alpha and PP2A beta.
Gene Name	ppp2cb
Protein Name
Other Name	PP2A beta; / PP2A-beta; / PP2AB_HUMAN; / PP2Abeta; / PP2CB; / Ppp2cb; / Protein phosphatase 2; / formerly 2A; / , catalytic subunit, beta isoform; / Protein phosphatase 2 catalytic subunit beta isozyme; / Protein phosphatase 2, catalytic subunit, beta isoform; / Protein phosphatase 2A catalytic subunit beta isoform; / Protein phosphatase type 2A catalytic subunit; / Serine/threonine protein phosphatase 2A catalytic subunit beta; / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.
Species	Human
Gene ID	5516
Uniprot	P62714,
Species.1	Mouse
Gene ID.1
Uniprot.1	P62715
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
Tissue Expression	Fibroblast,Heart,Kidney,Liver,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Cell growth and death >> Cell cycle;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Nervous system >> Dopaminergic synapse;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas	>>mRNA surveillance pathway; / >>Sphingolipid signaling pathway; / >>Oocyte meiosis; / >>Autophagy - other; / >>Autophagy - animal; / >>PI3K-Akt signaling pathway; / >>AMPK signaling pathway; / >>Adrenergic signaling in cardiomyocytes; / >>TGF-beta signaling pathway; / >>Hippo signaling pathway; / >>Tight junction; / >>Dopaminergic synapse; / >>Long-term depression; / >>Chagas disease; / >>Hepatitis C; / >>Human papillomavirus infection
Function	Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,Function:PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.,PTM:Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.,PTM:Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subcellular location:In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.,subunit:PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits.,

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PP2A α and β mouse mAb

Product details

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PP2A α and β mouse mAb

Product details

Specifications

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