Protein Z Monoclonal Antibody
Ucallm_WM0385-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
Specifications
| Size | 50μL/100μL |
| Target | Protein Z |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 45kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 7G10 |
| Immunogen | Purified recombinant fragment of Protein Z expressed in E. Coli. |
| Specificity | Protein Z Monoclonal Antibody detects endogenous levels of Protein Z protein. |
| Gene Name | PROZ |
| Protein Name | Vitamin K-dependent protein Z |
| Other Name | PROZ; / Vitamin K-dependent protein Z |
| Species | Human |
| Gene ID | 8858 |
| Uniprot | P22891, |
| Species.1 | Mouse |
| Gene ID.1 | 66901 |
| Uniprot.1 | Q9CQW3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Plasma. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity.,Function:Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,tissue specificity:Plasma., |
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