PTH Monoclonal Antibody
Ucallm_WM0387-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Specifications
| Size | 50μL/100μL |
| Target | Parathyroid Hormone |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 13kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 4H5 |
| Immunogen | Purified recombinant fragment of human PTH (aa1-115) expressed in E. Coli. |
| Specificity | PTH Monoclonal Antibody detects endogenous levels of PTH protein. |
| Gene Name | PTH |
| Protein Name | Parathyroid hormone |
| Other Name | Parathyroid hormone; / PTH; / Parathormone; / Parathyrin |
| Species | Human |
| Gene ID | 5741 |
| Uniprot | P01270 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Immune disease >> Rheumatoid arthritis |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Parathyroid hormone synthesis, secretion and action; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Rheumatoid arthritis |
| Function | Disease:Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.,Function:PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.,online information:Parathyroid hormone entry,similarity:Belongs to the parathyroid hormone family., |
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