Price range: $288.00 through $368.00
Background:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
| Target | Rb |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 106kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | |
| Modification | Phospho |
| Recommended Dilution Ratio | IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser788. AA range:756-805 |
| Sequence | |
| Specificity | Phospho-Rb (S788) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S788. |
| Gene Name | RB1 |
| Protein Name | Retinoblastoma-associated protein |
| Alias | RB1;Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110 |
| Organism-1 | Human |
| Gene ID-1 | 5925 |
| SwissProt-1 | P06400 |
| Organism-2 | Mouse |
| Gene ID-2 | 19645 |
| SwissProt-2 | P13405 |
| Organism-3 | Rat |
| Gene ID-3 | 24708 |
| SwissProt-3 | P33568 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. . |
