Product details
Background:
RDH12 rabbit pAb
Ucallm_WP8459-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RDH12 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RDH12 |
| Specificity | This antibody detects endogenous levels of RDH12 at Human, Mouse |
| Gene Name | RDH12 |
| Protein Name | Retinol dehydrogenase 12 (All-trans and 9-cis retinol dehydrogenase) |
| Other Name | |
| Species | Human |
| Gene ID | 145226 |
| Uniprot | Q96NR8, |
| Species.1 | Mouse |
| Gene ID.1 | 77974 |
| Uniprot.1 | Q8BYK4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane . |
| Tissue Expression | Widely expressed, mostly in retina, kidney, brain, skeletal muscle, pancreas and stomach. |
| Signaling_pathway | |
| Research Areas | |
| Function | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol . Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal . May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation . Has no dehydrogenase activity towards steroids . |
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