Recombinant CD141 Fc-Fused Nanobody (VF0392)
Ucallm_WN0092
$365.00
Product details
Background:The protein encoded byThis intronless gene is an endothelial-specific type I membrane receptor that binds thrombin.This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations inThis gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD64 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0024 |
| Immunogen | Purified recombinant Human CD141 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD141 protein. |
| Gene Name | THBD THRM |
| Protein Name | Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141) |
| Other Name | Thrombomodulin; / TM; / Fetomodulin; / CD antigen CD141 |
| Species | Human |
| Gene ID | 2209 |
| Uniprot | P07204, |
| Species.1 | Mouse |
| Gene ID.1 | 14129 |
| Uniprot.1 | P26151 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Monocyte/macrophage specific. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Human Diseases >> Immune disease >> Systemic lupus erythematosus |
| Research Areas | >>Phagosome; / >>Osteoclast differentiation; / >>Neutrophil extracellular trap formation; / >>Hematopoietic cell lineage; / >>Fc gamma R-mediated phagocytosis; / >>Leishmaniasis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia; / >>Systemic lupus erythematosus |
| Function | Disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin., |
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