Recombinant CD162 Fc-Fused Nanobody (VF0285)
Ucallm_WN0124
$365.00
Product details
Background:CD162, also known as p-selectin glycoprotein ligand-1 (PSGL-1), is a 120 – 220 kD, mucin-like type I transmembrane glycoprotein. CD162 binds to CD62P (P-Selectin), CD62E (E-Selectin) and CD62L (L-Selectin). The interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest “rolling” of leukocytes on the lumenal surface of activated endothelium, and the interaction between leukocytes and activated platelets or other leukocytes found at sites of inflammation. CD162 is expressed on neutrophils, monocytes, and most lymphocytes including NK and T cells but PSGL-1 stains B cells at significantly lower levels than other cell types.
Specifications
| Size | 100μL |
| Target | CD162 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0540 |
| Immunogen | Purified recombinant Human CD162 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD162 protein. |
| Gene Name | SELPLG |
| Protein Name | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) |
| Other Name | CLA; / CD162; / PSGL1; / PSGL-1; / PSGL-1; / p-selectin glycoprotein ligand-1; / CD 162 antibody; / CD162 antibody; / CD162 antigen antibody; / CLA antibody; / Cutaneous lymphocyte associated associated antigen antibody; / P selectin glycoprotein ligand 1 antibody; / P selectin glycoprotein ligand 1 precursor antibody; / P-selectin glycoprotein ligand 1 antibody; / PSGL 1 antibody; / PSGL-1 antibody; / PSGL1 antibody; / Selectin P ligand antibody; / SELPL_HUMAN antibody; / SELPLG antibody |
| Species | Human |
| Gene ID | 6404 |
| Uniprot | Q14242 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Found in most T-lymphocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
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