Recombinant CD183 Fc-Fused Nanobody (VF0090)
Ucallm_WN0132
$365.00
Product details
Background:CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.
Specifications
| Size | 100μL |
| Target | CD183 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0568 |
| Immunogen | Purified recombinant Human CD183 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD183 protein. |
| Gene Name | CXCR3 GPR9 |
| Protein Name | C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) |
| Other Name | CXCR3; / G protein-coupled receptor 9; / GPR9; / CKR-L2; / IP10 receptor; / IP10-R; / Mig receptor; / Mig-R; / C-X-C chemokine receptor type 3 antibody; / CD 183 antibody; / CD182 antibody; / CD183 antibody; / Chemokine; / C X C motif; / receptor 3 antibody; / Chemokine; / C X C; / receptor 3 antibody; / Chemokine CXC Motif Receptor 3 antibody; / CKR L2 antibody; / CKR-L2 antibody; / CKRL2 antibody; / CMKAR3 antibody; / CXC-R3 antibody; / CXCR-3 antibody; / CXCR3 antibody; / CXCR3_HUMAN antibody; / G Protein Coupled Receptor 9 antibody; / G protein-coupled receptor 9 antibody; / GPR9 antibody; / Interferon-inducible protein 10 receptor antibody; / IP-10 receptor antibody; / IP10 antibody; / IP10 R antibody; / IP10 receptor antibody; / IP10-R antibody; / IP10R antibody; / Mig R antibody; / Mig receptor antibody; / Mig-R antibody; / MIGR antibody |
| Species | Human |
| Gene ID | 2833 |
| Uniprot | P49682 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Liver,Pancreas,Placenta,Plasma,Testis |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | |
| Function | Isoform 1 is a Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis. Isoform 3 is mediates the activity of CXCL11. |
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