Recombinant CD19 Fc-Fused Nanobody (VF0613)
Ucallm_WN0156
$365.00
Product details
Background:CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD19 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0544 |
| Immunogen | Purified recombinant Human CD19 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD19 protein. |
| Gene Name | CD19 |
| Protein Name | B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) |
| Other Name | B-lymphocyte antigen CD19; / Cd19; / Differentiation antigen CD19; / CD19; / Antibody deficiency due to defect in CD19 antibody; / Antibody deficiency due to defect in CD19; / included antibody; / AW495831 antibody; / B lymphocyte antigen CD19 antibody; / B lymphocyte surface antigen B4 antibody; / B-lymphocyte antigen CD19 antibody; / B-lymphocyte surface antigen B4 antibody; / B4 antibody; / CD19 antibody; / CD19 antigen antibody; / CD19 molecule antibody; / Cd19 protein antibody; / CD19_HUMAN antibody; / CVID3 antibody; / Differentiation antigen CD19 antibody; / Leu 12 antibody; / Leu-12 antibody; / Leu12 antibody; / MGC109570 antibody; / MGC12802 antibody; / T-cell surface antigen Leu-12 antibody |
| Species | Human |
| Gene ID | 930 |
| Uniprot | P15391 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Membrane raft; Single-pass type I membrane protein . |
| Tissue Expression | Blood,PCR rescued clones,Placenta,Spleen |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> B cell receptor signaling pathway;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | |
| Function | Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge . |
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