$365.00
Background:The protein encoded byThis gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production.This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described forThis gene.[provided by RefSeq, Jul 2011]
| Size | 100μL |
| Target | CD23 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0258 |
| Immunogen | Purified recombinant Human CD23 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD23 protein. |
| Gene Name | FCER2 CD23A CLEC4J FCE2 IGEBF |
| Protein Name | Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] |
| Other Name | Blast 2 antibody; / BLAST-2 antibody; / Blast2 antibody; / C type lectin domain family 4 member J antibody; / C-type lectin domain family 4 antibody; / C-type lectin domain family 4 member J antibody; / C-type lectin domain family 4; / member J antibody; / CD 23 antibody; / CD 23A antibody; / CD23 antibody; / CD23 antigen antibody; / CD23A antibody; / CLEC 4J antibody; / CLEC4J antibody; / Fc epsilon receptor II antibody; / Fc epsilon RII antibody; / Fc fragment of IgE antibody; / Fc fragment of IgE low affinity II receptor for antibody; / Fc fragment of IgE receptor II antibody; / Fc fragment of IgE; / low affinity II; / receptor for; / CD23; / antibody; / Fc of IgE antibody; / Fc of IgE; / low affinity II; / receptor for; / CD23; / antibody; / Fc receptor IgE low affinity II alpha polypeptide antibody; / Fc receptor; / IgE; / low affinity II; / alpha polypeptide; / isoform CRA_a antibody; / Fc-epsilon-RII antibody; / FCE 2 antibody; / FCE2 antibody; / FCER 2 antibody; / Fcer2 antibody; / FCER2_HUMAN antibody; / FCER2A antibody; / FceRII antibody; / IgE binding factor antibody; / IgE receptor lymphocyte antibody; / IgE-binding factor antibody; / IGEBF antibody; / Immunoglobulin E binding factor antibody; / Immunoglobulin E receptor antibody; / Immunoglobulin E receptor; / low affinity II antibody; / Immunoglobulin E-binding factor antibody; / Immunoglobulin epsilon chain antibody; / LEUKOCYTE ANTIGEN CD23 antibody; / Low Affinity IgE Receptor antibody; / Low affinity immunoglobulin epsilon Fc receptor antibody; / Low affinity immunoglobulin epsilon Fc receptor membrane bound form antibody; / Low affinity immunoglobulin epsilon Fc receptor soluble form antibody; / Ly-42 antibody; / Ly42 antibody; / Lymphocyte antigen CD23 antibody; / Lymphocyte IgE receptor antibody; / MGC93219 antibody; / CD23 nanobody |
| Species | Human |
| Gene ID | 2208 |
| Uniprot | P06734 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Also exists as a soluble excreted form, sCD23. |
| Tissue Expression | Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:175838). Expressed on neutrophils (at protein level) (PubMed:175838). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311). |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage |
| Research Areas | |
| Function | This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).,miscellaneous:There are two kinds of Fc receptors for IgE, which differ in both structure and high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.,online information:CD23,PTM:N- and O-glycosylated.,similarity:Contains 1 C-type lectin domain.,subcellular location:Also exists as a soluble excreted form., |
