Recombinant CD314/NKG2D Fc-Fused Nanobody (VF0148)
Ucallm_WN0285
$365.00
Product details
Background:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of
Specifications
| Size | 100μL |
| Target | CD314/NKG2D |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0261 |
| Immunogen | Purified recombinant Human CD314 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD314/NKG2D protein. |
| Gene Name | KLRK1 D12S2489E NKG2D |
| Protein Name | NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314) |
| Other Name | NKG2-D type II integral membrane protein; / Killer cell lectin-like receptor subfamily K member 1; / NK cell receptor D; / NKG2-D-activating NK receptor; / CD antigen CD314; / CD314 nanobody; / NKG2D nanobody |
| Species | Human |
| Gene ID | 22914 |
| Uniprot | P26718 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . Colocalized with HCST on the cell surface. |
| Tissue Expression | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity |
| Research Areas | |
| Function | Alternative products:A number of isoforms are produced,Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.,miscellaneous:Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.,online information:NKG-2D,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.,tissue specificity:Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs)., |
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