Recombinant CD54 Fc-Fused Nanobody (VF0344)
Ucallm_WN0405
$365.00
Product details
Background:This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD54 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0120 |
| Immunogen | Purified recombinant Human CD54 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD54 protein. |
| Gene Name | ICAM1 |
| Protein Name | Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) |
| Other Name | Antigen identified by monoclonal antibody BB2 antibody; / BB 2 antibody; / BB2 antibody; / CD 54 antibody; / CD_antigen=CD54 antibody; / CD54 antibody; / Cell surface glycoprotein P3.58 antibody; / Human rhinovirus receptor antibody; / ICAM 1 antibody; / ICAM-1 antibody; / ICAM1 antibody; / ICAM1_HUMAN antibody; / intercellular adhesion molecule 1; / CD54; / antibody; / intercellular adhesion molecule 1; / CD54; / human rhinovirus receptor antibody; / Intercellular adhesion molecule 1 antibody; / Major group rhinovirus receptor antibody; / MALA 2 antibody; / MALA2 antibody; / MyD 10 antibody; / MyD10 antibody; / P3.58 antibody; / Surface antigen of activated B cells antibody; / Surface antigen of activated B cells; / BB2 antibody; / CD54 nanobody |
| Species | Human |
| Gene ID | 3383 |
| Uniprot | P05362 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Detected on umbilical veil endothelial cells (PubMed:162579). Detected in placenta (at protein level) (PubMed:169283). Detected on endothelial cells (PubMed:169283). |
| Signaling_pathway | Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus., |
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