Name: Recombinant CD62L Fc-Fused Nanobody (VF0037)
SKU: WN0427
Price: 365 USD
Availability: InStock

Recombinant CD62L Fc-Fused Nanobody (VF0037)

Ucallm_WN0427

$365.00

Product details

Background:CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer’s patches. It also plays a role in leukocyte rolling on activated endothelial cells.

Specifications

Size	100μL
Target	CD62L
Reactivity	Human
Applications	ELISA, FC
MW(Calculated)
MW(Observed)
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0506
Immunogen	Purified recombinant Human CD62L
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD62L protein.
Gene Name	SELL LNHR LYAM1
Protein Name	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Other Name	TQ1; / LAM1; / LEU8; / LNHR; / LSEL; / CD62L; / LYAM1; / PLNHR; / LECAM1; / L-selectin; / LECAM-1; / SELL; / LAM-1; / TQ-1; / MEL-14; / CD62L nanobody
Species	Human
Gene ID	6402
Uniprot	P14151
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein .
Tissue Expression	Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level).
Signaling_pathway	Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas
Function	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).