Recombinant CD62L Fc-Fused Nanobody (VF0038)
Ucallm_WN0428
$365.00
Product details
Background:CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer’s patches. It also plays a role in leukocyte rolling on activated endothelial cells.
Specifications
| Size | 100μL |
| Target | CD62L |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0306 |
| Immunogen | Purified recombinant Human CD62L |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD62L protein. |
| Gene Name | SELL LNHR LYAM1 |
| Protein Name | L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L) |
| Other Name | TQ1; / LAM1; / LEU8; / LNHR; / LSEL; / CD62L; / LYAM1; / PLNHR; / LECAM1; / L-selectin; / LECAM-1; / SELL; / LAM-1; / TQ-1; / MEL-14; / CD62L nanobody |
| Species | Human |
| Gene ID | 6402 |
| Uniprot | P14151 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>EGFR tyrosine kinase inhibitor resistance; / >>Endocrine resistance; / >>Platinum drug resistance; / >>MAPK signaling pathway; / >>ErbB signaling pathway; / >>Calcium signaling pathway; / >>HIF-1 signaling pathway; / >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>Adherens junction; / >>Tight junction; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>MicroRNAs in cancer; / >>Pancreatic cancer; / >>Endometrial cancer; / >>Prostate cancer; / >>Bladder cancer; / >>Non-small cell lung cancer; / >>Breast cancer; / >>Gastric cancer; / >>Central carbon metabolism in cancer |
| Function | Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). |
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