Repac Polyclonal Antibody
Ucallm_WP14253-50
Price range: $268.00 through $328.00
Product details
Background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],
Specifications
| Size | 50μL/100μL |
| Target | Repac |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RAPGEF5. AA range:431-480 |
| Specificity | Repac Polyclonal Antibody detects endogenous levels of Repac protein. |
| Gene Name | RAPGEF5 |
| Protein Name | Rap guanine nucleotide exchange factor 5 |
| Other Name | RAPGEF5; / GFR; / KIAA0277; / MRGEF; / Rap guanine nucleotide exchange factor 5; / Guanine nucleotide exchange factor for Rap1; / M-Ras-regulated Rap GEF; / MR-GEF; / Related to Epac; / Repac |
| Species | Human |
| Gene ID | 9771 |
| Uniprot | Q92565, |
| Species.1 | Mouse |
| Gene ID.1 | 217944 |
| Uniprot.1 | Q8C0Q9, |
| Species.2 | Rat |
| Gene ID.2 | 362799 |
| Uniprot.2 | P83900 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Widely expressed with highest levels in brain. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway |
| Research Areas | >>Ras signaling pathway; / >>Rap1 signaling pathway |
| Function | Function:Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in brain., |
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