Ribosomal Protein S19 Polyclonal Antibody
Ucallm_WP14326-50
Price range: $268.00 through $328.00
Product details
Background:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins
Specifications
| Size | 50μL/100μL |
| Target | Ribosomal Protein S19 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 16kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RPS19. AA range:81-130 |
| Specificity | Ribosomal Protein S19 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S19 protein. |
| Gene Name | RPS19 |
| Protein Name | 40S ribosomal protein S19 |
| Other Name | RPS19; / 40S ribosomal protein S19 |
| Species | Human |
| Gene ID | 6223 |
| Uniprot | P39019, |
| Species.1 | Mouse |
| Gene ID.1 | 20085 |
| Uniprot.1 | Q9CZX8, |
| Species.2 | Rat |
| Gene ID.2 | 29287 |
| Uniprot.2 | P17074 |
| Cellular Localization | Nucleus . Located more specifically in the nucleoli. |
| Tissue Expression | Higher level expression is seen in the colon carcinoma tissue than normal colon tissue. |
| Signaling_pathway | |
| Research Areas | >>Ribosome; / >>Coronavirus disease - COVID-19 |
| Function | Disease:Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1) [MIM:105650]. DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,Function:Required for pre-rRNA processing and maturation of 40S ribosomal subunits.,similarity:Belongs to the ribosomal protein S19e family.,subcellular location:Located more specifically in the nucleoli.,subunit:Interacts with RPS19BP1.,tissue specificity:Higher level expression is seen in the colon carcinoma tissue than normal colon tissue., |
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