Price range: $268.00 through $328.00
Background:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | RN5A |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 82kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RN5A AA range: 248-298 |
| Specificity | This antibody detects endogenous levels of RN5A at Human/Mouse |
| Gene Name | RNASEL RNS4 |
| Protein Name | RN5A |
| Other Name | |
| Species | Human |
| Gene ID | 6041 |
| Uniprot | Q05823, |
| Species.1 | Mouse |
| Gene ID.1 | 24014 |
| Uniprot.1 | Q05921 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Mitochondrion . |
| Tissue Expression | Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>NOD-like receptor signaling pathway; / >>Hepatitis C; / >>Influenza A; / >>Herpes simplex virus 1 infection |
| Function | Catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,Disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,Domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,Domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,Function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.,induction:By interferons.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 ANK repeats.,subunit:Monomer (inactive form) or homodimer.,tissue specificity:Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes., |
