RNase T2 rabbit pAb
Ucallm_WP6588-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | RNASET2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 28kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RNase T2 |
| Specificity | This antibody detects endogenous levels of RNase T2 at Human, Mouse |
| Gene Name | RNASET2 RNASE6PL |
| Protein Name | Ribonuclease T2 (Ribonuclease 6) |
| Other Name | |
| Species | Human |
| Gene ID | 8635 |
| Uniprot | O00584, |
| Species.1 | Mouse |
| Gene ID.1 | 100037283 |
| Uniprot.1 | Q9CQ01 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . Lysosome lumen . Endoplasmic reticulum lumen . Mitochondrion intermembrane space . Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. . |
| Tissue Expression | Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs . |
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