Product details
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RNF2 rabbit pAb
Ucallm_WP6219-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RNF2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 37kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RNF2 |
| Specificity | This antibody detects endogenous levels of RNF2 at Human, Mouse,Rat |
| Gene Name | RNF2 BAP1 DING HIPI3 RING1B |
| Protein Name | E3 ubiquitin-protein ligase RING2 (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) |
| Other Name | |
| Species | Human |
| Gene ID | 6045 |
| Uniprot | Q99496, |
| Species.1 | Mouse |
| Gene ID.1 | 19821 |
| Uniprot.1 | Q9CQJ4, |
| Species.2 | Rat |
| Gene ID.2 | 304850 |
| Uniprot.2 | Q4KLY4 |
| Cellular Localization | Nucleus . Cytoplasm . Chromosome . Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation . H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility . E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 . Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity). |
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