RRBP1 Polyclonal Antibody
Ucallm_WP1660-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012],
Specifications
| Size | 50μL/100μL |
| Target | RRBP1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 155kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1120-1200 |
| Specificity | RRBP1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RRBP1 KIAA1398 |
| Protein Name | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) |
| Other Name | |
| Species | Human |
| Gene ID | 6238 |
| Uniprot | Q9P2E9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99PL5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type III membrane protein . |
| Tissue Expression | Brain,Epithelium,Pancreas,Uterus, |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum |
| Function | Alternative products:Additional isoforms seem to exist. Additional isoforms are probable deriving from alternative splicing in the repeat region,Function:Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane., |
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