Price range: $268.00 through $328.00
Background:
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | RTN4R |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 52kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 270-350 |
| Specificity | RTN4R Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RTN4R NOGOR UNQ330/PRO526 |
| Protein Name | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) |
| Other Name | |
| Species | Human |
| Gene ID | 65078 |
| Uniprot | Q9BZR6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99PI8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q99M75 |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Cell projection, axon . Perikaryon . Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. . |
| Tissue Expression | Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter). |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.,online information:Nerve regrowth: nipped by a no-go - Issue 69 of April 2006,similarity:Belongs to the Nogo receptor family.,similarity:Contains 9 LRR (leucine-rich) repeats.,subunit:Homomultimer. Interacts with LINGO1.,tissue specificity:Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not expressed in oligodendrocytes (white matter)., |
