SKU: WP3077 Categories: ,

RXFP1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP3077-100
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Product details

Background:

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Specifications

Size50μL/100μL
TargetRXFP1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)83kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 240-320
SpecificityRXFP1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameRXFP1 LGR7
Protein NameRelaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1)
Other Name
SpeciesHuman
Gene ID59350
UniprotQ9HBX9,
Species.1Mouse
Gene ID.1
Uniprot.1Q6R6I7,
Species.2Rat
Gene ID.2
Uniprot.2Q6R6I6
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionExpressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Relaxin signaling pathway
Research Areas>>Neuroactive ligand-receptor interaction; / >>Relaxin signaling pathway
FunctionFunction:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.,
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