RXFP1 Polyclonal Antibody
Ucallm_WP3077-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Specifications
| Size | 50μL/100μL |
| Target | RXFP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 83kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 240-320 |
| Specificity | RXFP1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RXFP1 LGR7 |
| Protein Name | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) |
| Other Name | |
| Species | Human |
| Gene ID | 59350 |
| Uniprot | Q9HBX9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6R6I7, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q6R6I6 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Relaxin signaling pathway |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Relaxin signaling pathway |
| Function | Function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen., |
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