Price range: $268.00 through $328.00
Background:
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
| Size | 50μL/100μL |
| Target | S12A2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 133kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from C-Ternal of human protein |
| Specificity | S12A2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SLC12A2 NKCC1 |
| Protein Name | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) |
| Other Name | |
| Species | Human |
| Gene ID | 6558 |
| Uniprot | P55011, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P55012 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in many tissues. |
| Signaling_pathway | |
| Research Areas | >>Salivary secretion; / >>Pancreatic secretion; / >>Vibrio cholerae infection |
| Function | Function:Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SLC12A transporter family.,tissue specificity:Expressed in many tissues., |
