SKU: WP1770 Categories: ,

S20A1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1770-100
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Product details

Background:

The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011],

Specifications

Size50μL/100μL
TargetS20A1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)74kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityS20A1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSLC20A1 GLVR1 PIT1
Protein NameSodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)
Other Name
SpeciesHuman
Gene ID6574
UniprotQ8WUM9,
Species.1Mouse
Gene ID.1
Uniprot.1Q61609,
Species.2Rat
Gene ID.2
Uniprot.2Q9JJP0
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionUbiquitously expressed.
Signaling_pathway
Research Areas
FunctionDomain:Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.,Function:Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).,induction:By phosphate deprivation as well as by interleukin-8 in hypertrophic chondrocytes.,similarity:Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.,tissue specificity:Ubiquitously expressed.,
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