S2610 rabbit pAb
Ucallm_WP3519-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | S2610 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human S2610 AA range: 295-345 |
| Specificity | This antibody detects endogenous levels of S2610 at Human/Mouse |
| Gene Name | SLC26A10 |
| Protein Name | S2610 |
| Other Name | Solute carrier family 26 member 10 |
| Species | Human |
| Gene ID | 65012 |
| Uniprot | Q8NG04, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q5EBI0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Cerebellum,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,Domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,Function:Chloride/bicarbonate exchanger.,Function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 STAS domain.,subcellular location:Highly colocalizes with actin regions.,subunit:Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.,tissue specificity:Isoforms 1 and 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver., |
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