Price range: $268.00 through $328.00
Background:
function:Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation., similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family., subunit:Interacts with LIN7C., tissue specificity:Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.,
| Size | 50μL/100μL |
| Target | S6A12 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 67kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | S6A12 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SLC6A12 |
| Protein Name | Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) |
| Other Name | |
| Species | Human |
| Gene ID | 6539 |
| Uniprot | P48065, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P31651, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P48056 |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Expression | Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>Synaptic vesicle cycle; / >>GABAergic synapse |
| Function | Function:Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subunit:Interacts with LIN7C.,tissue specificity:Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain., |
